EMBOSS Water lt Pairwise Sequence Alignment lt EMBL EBI EMBOSS Water uses the Smith Waterman algorithm modified for speed enhancements to calculate the local alignment of two sequences. This is the form for protein sequences. Introduction To Research In The Health Sciences Pdf Software. Please go to the nucleotide form if you wish to align DNA or RNA sequences. If you plan to use these services during a course please contact us. Protein Alignment Program' title='Protein Alignment Program' />Return to FAQ Table of Contents. Download Design Program Steel Truss Software here. Blat vs. Blast What are the differences between Blat and Blast Blat is an alignment tool like BLAST, but it is structured differently. Pairwise Alignment Form SSearch SmithWaterman fulllength alignments between two sequences.